Generate your single-domain antibodies (VHH) in 6 weeks using AI and biological tools, for impactful research.
IMMUNOCHEM’s EVOBodies™ platforms works from any antigen, even toxic or non-immunogenic ones. We offer AI-constructed VHH to help Scientific Managers in Bio-Pharmaceutical companies streamline their processes, get rid off time spent on unpredictability, and achieve the results they deserve.
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Are you struggling to generate reliable and precise antigen-binding molecules?
Are you frustrated by the complexity and difficulty of generating precise antibodies against your targets?
Are you tired of time-consuming mAbs generation campaigns and betting on uncertain immunization results?
Are you part of the 86% of labs suffering from the lack of reproducibility?
Are you concerned that unreliable antibodies could jeopardize your entire research project, wasting months or even years of work?
If you answered yes to at least one of those questions, take a moment to read on to discover how we can help.
We know how it feels to lose time, energy, and resources, ending up exhausted with inconclusive results.
Before beeing experts, we also struggled to find solutions by ourselves. We imagined, explored and tested various existing methods, including immunization in mice, rats, and rabbits. We also attempted recombinant expression in CHO and HEK cells. We even tested exotic methodology such as those you read in the litterature but which never works.... ... And nothing came out.
We are Scientific Entrepreneurs. We understand the economic vision behind your project.
You shouldn’t struggle to generate antigen-binding molecule as starting materials for your crucial research. Unpredictable solutions shouldn't compromise your work. Through EVOBodies™ platform, IMMUNOCHEM provides precise AI-driven antibody discovery, helping bio-pharmaceutical managers and scientists save time, reduce stress, and achieve the groundbreaking research results they deserve.
What if you could create your tailored antibody with controllable, predictable AI-based biology?
Now, imagine you are working without the stress incumbent upon chance-relying results. Because your antigen-binding molecule have been stricly well design upon your wishes.
From now, you own the perfect material to target and detect your antigens and you perform your experiments with high-reproductibility.
Visualize your science moving forward in flow. You are waiting confident the end of your day experience. Your missing experiences are not any more a conversation subject since you conquer your antibody construction.
You take pleasure in your science. And you can finally allocate more of your time to strategy instead of energy-consuming failing experiment.
How single-domain antibodies are a game-changer for your projects ?
Camelids such as alpacas produce heavy chain-only IgGs (HCAb). Their antigen-binding domain (Fab fragment) lacks the CH1 domain of the heavy chain, and the light chains are also absent.
Single-domain antibodies or VHH are the equivalent of the variable domain of camelid heavy chain antibodies. As the smallest binding entity, being only 15kDa, they offer significant advantages in research and therapeutic applications.
Working with VHH means that you’re opting for a more efficient, more reliable, and more confident path to success.
Here’s why working with VHH is a great choice for your research
Predictable : VHH are designed upon request by leveraging computational modeling (AI), ensuring predictability.
Efficient : VHH are produced by leveraging synthetic biology, avoiding random immunisation results.
Simple : VHH are produced in microbial systems, meaning simplified production process, saving you time and resources.
Small : VHH are only 15KDa, demonstrating enhanced tissue penetration, reaching hidden and cryptic epitopes not accessible with conventional mAbs.
Stable: VHH are highly stable even under challenging conditions, maintaining their effectiveness upon time. Shelf-life is no longer an issue!
Easy to engineer : VHH are highly versatile and can be customized for various applications through advanced protein engineering, providing tailored solutions to meet your specific projects needs.
Leveraging Artificial Intelligence for enhanced antibody and VHH solutions
Today, by combining AI and biological tools, you have the power in your hand to create your tailored antibodies in only a few weeks, rather than waiting months for unpredictable results from traditional immunization processes.
What's even better for you? This method works for any antigen, including:
little or non-immunogenic
toxic to the host
highly conserved
targeting vital functions
Using Artificial Intelligence to generate VHH means :
You don’t need the physical antigen.
You built everything from scratch from its sequence (de novo generation).
You accelerate your pipeline for developing therapeutic antibodies.
You improve the developability of your molecules.
You own detailed reports of AI analyses that predict the characteristics of your VHH.
Take advantage of VHH in your own field of applications
In Biotech & Pharma
- Target specific antigens that were impossible or difficult-to-access targets
- Switch from mAbs to VHH as molecules with numerous advantages
- Benefit from easy scale-up and reproducibility
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In diagnostics
- Switch your polyclonal antibody to VHH for more robust process
- Design precise pairs of VHH for your tests (CLIA, ELISA, LFA, etc.)
- Increase the sensitivity of your tests
In R&D
- Discover totally new VHH again your antigen
- Realize experiments with VHH even in the hardest conditions
- Reach cryptic or hidden antigens, identify conformational changes or idiotypes with precisely designed VHHs.
Create your single-domain antibody in 6 weeks effortlessly with our unique EVOBodies™ program
If you want to generate highly precise molecules, that will significantly impact your scientific developments, you can count on IMMUNOCHEM’s EVOBodies™ platform to help you succeed.
Define your antigen precisely
Select the antigen and the antigen sequence of interest.
Receive 3D VHH structure
Receive the generated sequence of VHH along with a brief report, including its 3D structure visualization.
Get your validated VHH
Receive the synthesized and validated VHH, ready to perform precise and reliable assays in your lab.
Meet Philippe Herman, CEO of Immunochem and passionate innovator in Life Sciences
Hello, I’m Philippe Herman ! I have been evolving for +12 years on the intersection of biophysics and computational biology.
I authored 20 papers studying microbial adhesion using the atomic force microscope. I had the chance to apply it to the fabulous world of microbes. I discovered and demonstrated key concepts in protein-host protein interactions for staphylococcal proteins. I notably wrote a PNAS paper in 2018 and was invited to write a Science perspective around the hospital-acquired infections.
I am passionate about how technique can help Science. During my research, I needed of precisely designed molecules against my antigens of interests.
This led me to discover the power of VHH, and inspired me to develop IMMUNOCHEM’s EVOBodies™ platform, making it accessible to our clients.
“I am committed to brigging the best solutions that shape the future of healthcare”
I am always eager to connect and assist professionals sharing a passion for biotechnology, driven to make an impact using Science.
Conduct innovative research for significant medical advancement by getting rid of unreliable materials or missed deadlines.
Predictable results
AI-driven discovery is the most optimal tool to design precisely any antigen-binding molecules such as VHH.
Save time on discovery process
Meet your deadlines thanks to our 6-week EVOBodies™ program. Keep your focus on the innovative aspects of your research, and leave stress behind.
No more animals
Receive the synthesized and validated VHH, ready to perform precise and reliable assays in your lab.
How to start your journey with IMMUNOCHRM to create your Single-Domain Antibodies (VHH) in 6 weeks ?
Take advantage of your EVOTwice warranty
To show you the confidence we have in our EVOBodies ™ platform, and for a limited time only, we offer to our new customers the EVOTwice warranty. If the VHH do not bind your target in your assay, we commit to a second round of EVOBodies™program at no cost, ensuring you have a reliable outcome.
Frequently asked questions
You will receive your VHH ready-to-test between 6 to 8 weeks after contract signature and kick-off meeting.
Antigen sequence is enough. But you may need the antigen at your disposal for validity testing in your lab.
After our kick-off meeting, the first phase will consist of generating a 3D structure of VHHs against your antigen of interest. If we consider the chance are low to generate a good binder, we won’t move forward.
IMMUNOCHEM is a company founded in 1998, preliminary providing a catalog of high quality antibody. Since 2020, the company specialises on VHH discovery and generation, leveraging biological as well as AI tools.
Through our EVOTwice™ warranty, we commit to pursue another round of VHH generation if you demonstrate that the VHH does not eventually perform correctly in your binding assay.
IMMUNOCHEM positions as a key partner in the discovery phases including VHH generation at small scale. For intence production, we will gladly suggest you some of our reliable partners.
If your country allows the reception of biologics, it means that we can work together
Still have a question?
If you need more information, please email us or book your discovery call.
If you want to achieve your scientific goals, you know there are only two possible choices.
The first choice is to continue as you always have.
Trying to generate antibodies through immunization without certainty about the molecules obtained, wasting money transferring your sequences for recombinant expression in sometimes exotic cells, and secretly envying those who easily generate their molecules of interest.
You are free to waste your time and continue to dream.
Or you have this second choice.
To invest in our EVOBodies™ program, to experience concrete scientific developments by generating your VHH in 6 weeks.
Against even the most complex targets.
Without randomness.
And become the leader who reassures his teams by his ability to identify solutions that lead research to success.
You are free to invest now to finally achieve your company's scientific objectives.
And with our EVOTwice warranty, you take no risk.
We know you can succeed by following a controlled process, like the other clients who trust us.
Start relying on predictable solutions to develop your processes with serenity
Apply for access to our VHH-testing group and receive a 3D visualization of your single-domain antibody against any antigen of interest. Currently, this service is free of charge for a limited number of participants